Lung Cancer Non Small Cell
UMLS: C0007131
Basic Information
Severity Level:
Critical
Definition:
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
UMLS ID:
C0007131
MeSH ID:
Synonyms:
Lung Cancer Non Small Cell
Lung Non-Small Cell Carcinoma
Nsclc - Non-Small Cell Lung Cancer
Nsclc - Non-Small Cell Lung Cancer
Non Small Cell Lung Cancer Nos
Non-Small Cell Cancer Of Lung
Non-Small Cell Cancer Of The Lung
Non-Small Cell Carcinoma Of Lung
Non-Small Cell Carcinoma Of The Lung
Non-Small Cell Lung Cancer
Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Cancer
Non-Small Cell Lung Cancer, Nos
Non-Small Cell Lung Carcinoma
Cancer Cell Lung Non Small
Cancer Cell Lung Non-Small
Cancer Cells Lung Non Small
Carcinoma Cell Lung Non Small
Carcinoma Cell Lung Non-Small
Lung Cancer Non Small Cell
Classification Hierarchy
MeSH Tree Number breakdown for C0007131
C04
Neoplasms
C04.588
Neoplasms by Site
C04.588.894
Thoracic Neoplasms
C04.588.894.797
Respiratory Tract Neoplasms
C08
Respiratory Tract Diseases
C08.381
Lung Diseases
C08.381.540
Lung Neoplasms
C08.381.540.140
Carcinoma, Bronchogenic
C08
Respiratory Tract Diseases
C08.785
Respiratory Tract Neoplasms
C08.785.520
Lung Neoplasms
ADE Molecular Mechanism Mapping
Drug-ADE-Human Protein Triplets
Molecular mechanism triplets showing drug-adverse event-protein relationships
771
Total Triplets
89
High Confidence
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Personalized Drug-Protein-ADE Network
Comprehensive Information for Personalized ADE
Comprehensive Information and Reliability for Drug-ADE Association
Drug Confidence Filter
DTA Confidence Level
Layout Style
Show Labels
Total Drugs
346
18 High |
25 Medium |
303 Low Confidence
Total Proteins
137
Target proteins associated with this ADE
Drug-Protein-ADE association
8961
26 Known |
63 High |
682 Middle |
8190 Low Confidence
Confidence Profile
9%
Known/High/Middle-confidence interactions
This interactive network visualization shows the relationships between the top 50 drugs (ranked by case number) out of 346 total drugs associated with this adverse event, their known and potential off-target proteins, and the associated adverse effect. The connections indicate binding interactions and mechanistic pathways.
Adverse Drug Event (ADE)
Drug
Protein
Drug-Center
Human Protein-Center
confidence level
Drug Confidence Level Distribution
Drug Type Distribution
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Pharmacological Target Class Distribution
Top 8 Function Target Sub Classes
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The Introduction of Drug-AE Confidence Score Grade
| Priority Level | Score Range | Description | Evidence Characteristics |
|---|---|---|---|
| High | Score ≥ 6.67High-priority associations requiring immediate attention. | Strong evidence across multiple dimensions with high statistical significance, robust association measures, and substantial case numbers. Warrant priority pharmacovigilance action. | High P-value scores (significant Adjust-P), Strong ROR/PRR values, Substantial case numbers, Complete dimensional coverage, Minimal data filtering needed. |
| Medium | 3.33 ≤ Score < 6.67Medium-priority associations requiring careful evaluation. | Moderate evidence quality with acceptable statistical significance and association strength. May need additional validation or monitoring before definitive action. | Moderate P-value significance, Reasonable ROR/PRR measures, Adequate case numbers, Partial dimensional coverage, Some data quality considerations. |
| Low | Score < 3.33Low-priority associations with limited evidence strength. | May represent weak signals, insufficient data, or associations requiring extensive additional investigation before any regulatory or clinical consideration. | Weak P-value significance, Low association measures, Limited case numbers, Incomplete dimensional data, Significant data filtering applied. |
The Introduction of Drug-AE Severity Score Grade
| Severity Level | Score Range | Description | Typical outcomes |
|---|---|---|---|
| Minimal | 0 ≤ Score ≤ 0.387 Low severity ADRs requiring minimal intervention. | Events that need medical attention to prevent permanent damage but without hospitalization or life-threatening consequences. | Primarily RI (Required Intervention) outcomes, Outpatient management, Preventive measures, Early intervention prevents escalation. |
| Mild | 0.387 < Score ≤ 0.861 Mild severity events requiring hospitalization. | Mix of intervention-required and hospitalization cases with manageable clinical outcomes and good recovery potential. | Mix of RI and HO outcomes, Initial or prolonged hospitalization, Active medical management, Generally favorable prognosis. |
| Moderate | 0.861 < Score ≤ 1.500 Moderate ADRs resulting in permanent disability. | Higher proportion of hospitalization and disability cases requiring intensive medical management and long-term care planning. | Increased HO and DS outcomes, Permanent disability, Extended hospitalization, Rehabilitation required, Long-term functional impairment. |
| Severe | 1.500 < Score ≤ 2.52High severity life-threatening events with significant morbidity. | Notable presence of disability and life-threatening outcomes requiring emergency intervention and intensive care management. | Prominent DS and LT outcomes, Life-threatening events, Emergency intervention required, ICU admission, High risk of permanent consequences. | Critical | 2.524 < Score ≤ 5.000Critical life-threatening or fatal ADRs with maximum clinical impact. | High proportion of life-threatening events and deaths with very strong drug-event associations requiring immediate regulatory action. | Significant LT and DE outcomes, Fatal events, Emergency life-support measures, Immediate drug discontinuation, Regulatory safety alerts. |
The Introduction of Drug-AE-Protein Confidence Score Grade
| Confidence Level | Relationships | Description | Evidence Types |
|---|---|---|---|
| Known/Valid | Direct DTA relationships | The drug-ADE, drug-target, and target-ADE associations are all derived from the same literature source. | Experimental validation, Clinical evidence |
| High | DT + TA + DA | Two of the three associations (drug-ADE, drug-target, and target-ADE) are derived from the same literature source, while the third is validated by other literature. | Multiple corroborating sources |
| Medium | DT + TA + DA | Two of the three associations (drug-ADE, drug-target, and target-ADE) are validated by separate literature sources. | Partial evidence chain |
| Low | TA + DT | Only target-ADE and drug-target associations are validated by literature sources. | Associative evidence only |
Personalized ADE
Route and Formulation-specified Associations
Pharmaceutic Granularity for Route and Formulation specification
Administration Routes (Total: 1757 cases across 11 routes)
Dosage Forms (Total: 1232 cases across 11 forms)
Drug Route Analysis
Drug Form Analysis
Drug Route Analysis
| Route | Drug Name | Case Number | Confidence Score | Confidence Level | Severity Score | Severity Level | Details | ||
|---|---|---|---|---|---|---|---|---|---|
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Drug Form Analysis
| Form | Drug Name | Case Number | Confidence Score | Confidence Level | Severity Score | Severity Level | Details | ||
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Disease-stratified Associations
Personalized Granularity for Disease and Indication Stratification
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Indication Name
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Drug Name
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Case Number
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Confidence Score
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Confidence Level
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Severity Score
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Severity Level
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Details |
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DEV TOOL
