Disorder;Panic

UMLS: C0030319
Basic Information
Severity Level:
Moderate
Definition:
A type of anxiety disorder characterized by unexpected panic attacks that last minutes or, rarely, hours. Panic attacks begin with intense apprehension, fear or terror and, often, a feeling of impending doom. Symptoms experienced during a panic attack include dyspnea or sensations of being smothered; dizziness, loss of balance or faintness; choking sensations; palpitations or accelerated heart rate; shakiness; sweating; nausea or other form of abdominal distress; depersonalization or derealization; paresthesias; hot flashes or chills; chest discomfort or pain; fear of dying and fear of not being in control of oneself or going crazy. Agoraphobia may also develop. Similar to other anxiety disorders, it may be inherited as an autosomal dominant trait.
UMLS ID:
C0030319
MeSH ID:
D016584
Synonyms:
Disorder;Panic
Episodic Paroxysmal Anxiety Disorder
Panic Disorder
Panic Disorder
Panic Disorder
Panic Disorder [Episodic Paroxysmal Anxiety]
Panic Disorders
Disorder; Panic
Panic Disorder
Panic Disorders
Panic; Disorder
ADE Molecular Mechanism Mapping

Drug-ADE-Human Protein Triplets

Molecular mechanism triplets showing drug-adverse event-protein relationships

37 Total Triplets
3 High Confidence
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Personalized Drug-Protein-ADE Network

Comprehensive Information for Personalized ADE

Comprehensive Information and Reliability for Drug-ADE Association

Drug Confidence Filter
DTA Confidence Level
Layout Style
Show Labels
Total Drugs
578
17 High | 58 Medium | 503 Low Confidence
Total Proteins
4
Target proteins associated with this ADE
Drug-Protein-ADE association
388
1 Known | 2 High | 34 Middle | 351 Low Confidence
Confidence Profile
10%
Known/High/Middle-confidence interactions

This interactive network visualization shows the relationships between the top 50 drugs (ranked by case number) out of 578 total drugs associated with this adverse event, their known and potential off-target proteins, and the associated adverse effect. The connections indicate binding interactions and mechanistic pathways.

Adverse Drug Event (ADE)
Drug
Protein
Drug-Center
Human Protein-Center
confidence level

Drug Confidence Level Distribution

Drug Type Distribution

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Pharmacological Target Class Distribution

Top 8 Function Target Sub Classes

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The Introduction of Drug-AE Confidence Score Grade
Priority Level Score Range Description Evidence Characteristics
High Score ≥ 6.67
High-priority associations requiring immediate attention. 		Strong evidence across multiple dimensions with high statistical significance, robust association measures, and substantial case numbers. Warrant priority pharmacovigilance action. High P-value scores (significant Adjust-P), Strong ROR/PRR values, Substantial case numbers, Complete dimensional coverage, Minimal data filtering needed.
Medium 3.33 ≤ Score < 6.67
Medium-priority associations requiring careful evaluation.		 Moderate evidence quality with acceptable statistical significance and association strength. May need additional validation or monitoring before definitive action. Moderate P-value significance, Reasonable ROR/PRR measures, Adequate case numbers, Partial dimensional coverage, Some data quality considerations.
Low Score < 3.33
Low-priority associations with limited evidence strength. 		May represent weak signals, insufficient data, or associations requiring extensive additional investigation before any regulatory or clinical consideration. Weak P-value significance, Low association measures, Limited case numbers, Incomplete dimensional data, Significant data filtering applied.
PersDTA overview
The Introduction of Drug-AE Severity Score Grade
Severity Level Score Range Description Typical outcomes
Minimal 0 ≤ Score ≤ 0.387
Low severity ADRs requiring minimal intervention.		 Events that need medical attention to prevent permanent damage but without hospitalization or life-threatening consequences. Primarily RI (Required Intervention) outcomes, Outpatient management, Preventive measures, Early intervention prevents escalation.
Mild 0.387 < Score ≤ 0.861
Mild severity events requiring hospitalization.		 Mix of intervention-required and hospitalization cases with manageable clinical outcomes and good recovery potential. Mix of RI and HO outcomes, Initial or prolonged hospitalization, Active medical management, Generally favorable prognosis.
Moderate 0.861 < Score ≤ 1.500
Moderate ADRs resulting in permanent disability.		 Higher proportion of hospitalization and disability cases requiring intensive medical management and long-term care planning. Increased HO and DS outcomes, Permanent disability, Extended hospitalization, Rehabilitation required, Long-term functional impairment.
Severe 1.500 < Score ≤ 2.52
High severity life-threatening events with significant morbidity.		 Notable presence of disability and life-threatening outcomes requiring emergency intervention and intensive care management. Prominent DS and LT outcomes, Life-threatening events, Emergency intervention required, ICU admission, High risk of permanent consequences.
Critical 2.524 < Score ≤ 5.000
Critical life-threatening or fatal ADRs with maximum clinical impact.		 High proportion of life-threatening events and deaths with very strong drug-event associations requiring immediate regulatory action. Significant LT and DE outcomes, Fatal events, Emergency life-support measures, Immediate drug discontinuation, Regulatory safety alerts.
The Introduction of Drug-AE-Protein Confidence Score Grade
Confidence Level Relationships Description Evidence Types
Known/Valid Direct DTA relationships The drug-ADE, drug-target, and target-ADE associations are all derived from the same literature source. Experimental validation, Clinical evidence
High DT + TA + DA Two of the three associations (drug-ADE, drug-target, and target-ADE) are derived from the same literature source, while the third is validated by other literature. Multiple corroborating sources
Medium DT + TA + DA Two of the three associations (drug-ADE, drug-target, and target-ADE) are validated by separate literature sources. Partial evidence chain
Low TA + DT Only target-ADE and drug-target associations are validated by literature sources. Associative evidence only
Personalized ADE

Route and Formulation-specified Associations

Pharmaceutic Granularity for Route and Formulation specification

Administration Routes (Total: 2308 cases across 19 routes)

Dosage Forms (Total: 1144 cases across 22 forms)

Drug Route Analysis
Drug Form Analysis

Drug Route Analysis

Route Drug Name Case Number Confidence Score Confidence Level Severity Score Severity Level Details
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Drug Form Analysis

Form Drug Name Case Number Confidence Score Confidence Level Severity Score Severity Level Details
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Disease-stratified Associations

Personalized Granularity for Disease and Indication Stratification

Indication Name
Drug Name
Case Number
Confidence Score
Confidence Level
Severity Score
Severity Level
Details