Cocaine
(ZPUCINDJVBIVPJ-LJISPDSOSA-N)
Approved
Basic Information
Molecular Structure
Molecular Formula:
C17H21NO4
Molecular Weight:
303.3529 g/mol
Synonyms:
Cocaine
Cocaine HCl
Cocaine Hydrochloride
Description
A tropane alkaloid with local anesthetic and vasoconstrictive properties. Clinically used in ENT procedures, cocaine is also a potent CNS stimulant and drug of abuse due to its dopamine reuptake inhibition.
Indication
Anesthesia
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ADE Molecular Mechanism Mapping

Drug-ADE-Human Protein Triplets

Molecular mechanism triplets showing drug-adverse event-protein relationships

857 Total Triplets
56 High Confidence
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Personalized Drug-Protein-ADE Network

Comprehensive Information for Personalized ADE

Comprehensive Information and Reliability for Drug-ADE Association

ADE Confidence Filter
DTA Confidence Level
Layout Style
Show Labels
Total ADEs
908
5 High | 32 Medium | 871 Low Confidence
Total Proteins
93
Human proteins associated with this ADE
Drug-ADE-Human Protein associations
3058
7 Known | 49 High | 801 Middle | 2201 Low Confidence
Confidence Profile
28%
Known/High-confidence interactions

This interactive network visualization shows the relationships between the top 50 ADEs (ranked by case number) out of 908 total ADEs associated with this drug, their known and related off-target proteins, and the associated adverse effect. The connections indicate binding interactions and mechanistic pathways.

Adverse Drug Event (ADE)
Drug
Protein
ADE-Center
Human Protein-Center
Confidence Level

ADE Confidence Level Distribution

ADE Type Distribution

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Pharmacological Target Class Distribution

Top 8 Function Target Sub Classes

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The Introduction of Drug-AE Confidence Score Grade
Priority Level Score Range Description Evidence Characteristics
High Score ≥ 6.67
High-priority associations requiring immediate attention. 		Strong evidence across multiple dimensions with high statistical significance, robust association measures, and substantial case numbers. Warrant priority pharmacovigilance action. High P-value scores (significant Adjust-P), Strong ROR/PRR values, Substantial case numbers, Complete dimensional coverage, Minimal data filtering needed.
Medium 3.33 ≤ Score < 6.67
Medium-priority associations requiring careful evaluation.		 Moderate evidence quality with acceptable statistical significance and association strength. May need additional validation or monitoring before definitive action. Moderate P-value significance, Reasonable ROR/PRR measures, Adequate case numbers, Partial dimensional coverage, Some data quality considerations.
Low Score < 3.33
Low-priority associations with limited evidence strength. 		May represent weak signals, insufficient data, or associations requiring extensive additional investigation before any regulatory or clinical consideration. Weak P-value significance, Low association measures, Limited case numbers, Incomplete dimensional data, Significant data filtering applied.
PersADE overview
The Introduction of Drug-AE Severity Score Grade
Severity Level Score Range Description Typical outcomes
Minimal 0 ≤ Score ≤ 0.387
Low severity ADRs requiring minimal intervention.		 Events that need medical attention to prevent permanent damage but without hospitalization or life-threatening consequences. Primarily RI (Required Intervention) outcomes, Outpatient management, Preventive measures, Early intervention prevents escalation.
Mild 0.387 < Score ≤ 0.861
Mild severity events requiring hospitalization.		 Mix of intervention-required and hospitalization cases with manageable clinical outcomes and good recovery potential. Mix of RI and HO outcomes, Initial or prolonged hospitalization, Active medical management, Generally favorable prognosis.
Moderate 0.861 < Score ≤ 1.500
Moderate ADRs resulting in permanent disability.		 Higher proportion of hospitalization and disability cases requiring intensive medical management and long-term care planning. Increased HO and DS outcomes, Permanent disability, Extended hospitalization, Rehabilitation required, Long-term functional impairment.
Severe 1.500 < Score ≤ 2.52
High severity life-threatening events with significant morbidity.		 Notable presence of disability and life-threatening outcomes requiring emergency intervention and intensive care management. Prominent DS and LT outcomes, Life-threatening events, Emergency intervention required, ICU admission, High risk of permanent consequences.
Critical 2.524 < Score ≤ 5.000
Critical life-threatening or fatal ADRs with maximum clinical impact.		 High proportion of life-threatening events and deaths with very strong drug-event associations requiring immediate regulatory action. Significant LT and DE outcomes, Fatal events, Emergency life-support measures, Immediate drug discontinuation, Regulatory safety alerts.
The Introduction of Drug-AE-Protein Confidence Score Grade
Confidence Level Relationships Description Evidence Types
Known/Valid Direct DTA relationships The drug-ADE, drug-target, and target-ADE associations are all derived from the same literature source. Experimental validation, Clinical evidence
High DT + TA + DA Two of the three associations (drug-ADE, drug-target, and target-ADE) are derived from the same literature source, while the third is validated by other literature. Multiple corroborating sources
Medium DT + TA + DA Two of the three associations (drug-ADE, drug-target, and target-ADE) are validated by separate literature sources. Partial evidence chain
Low TA + DT Only target-ADE and drug-target associations are validated by literature sources. Associative evidence only
Personalized ADE

Route and Formulation-specified Associations

Pharmaceutic Granularity for Route and Formulation specification

Administration Routes

Dosage Forms

Drug Route Analysis
Drug Form Analysis

Drug Route Analysis

Route ADE ID ADE Name Case Number Confidence Score Confidence Severity Score Severity Details
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Drug Form Analysis

Form ADE ID ADE Name Case Number Confidence Score Confidence Level Severity Score Severity Level Details
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Disease-stratified Associations

Personalized Granularity for Disease and Indication Stratification

Indication & ADE
Case Number
Confidence Score
Confidence Level
Severity Score
Severity Level
Details